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Classical Hodgkin Lymphoma : Nodular Sclerosis (Reed-Sternberg Cells)

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Hodgkin Lymphoma, Nodular Sclerosis, Reed-Sternberg Cells: The conventional definition of Hodgkin lymphoma requires the presence of Reed-Sternberg cells (many are seen in this image) in a characteristic background infiltrate composed of eosinophils, lymphocytes, plasma cells, and histiocytes. It lacks the monomorphic appearance of non-Hodgkin lymphomas. Variable degree of fibrosis is also present (depending upon the subtype).

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