Schwannoma : Ancient Change

Comments:
Deep-seated schwannomas (mediastinum or retroperitoneum) of long standing may show several degenerative changes. They include degenerative-type cytologic atypia (irregularly enlarged multilobed hyperchromatic nuclei, intranuclear vacuoles), cystic change, calcification, hemorrhage, and dense hyalinization. Several of those features are seen in this retroperitoneal schwannoma removed from an adult female.