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HPV in HIV Infection

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HPV lesions in HIV-infected patients: Anogenital warts are quite common in HIV-infected patients. In addition, warts can develop in unusual locations, such as lips, tongue, or oral mucosa in the setting of HIV infection. The initial treatment consists of standard regimens, including podophyllotoxin, cryotherapy, laser, or excisional surgery. However, in immunosuppressed patients genital lesions are often resistant to treatment and recur more often.

HPV-induced lesions can progress rapidly in HIV-infected hosts. Patient with extensive genital warts should be screened for HIV infection. There is increased risk of precancerous/dysplastic lesions as well as cancers of cervix, vulva, vagina, anus, and oropharynx. Cervical cancer is considered one of the AIDS-defining illnesses.

The image shows condyloma acuminatum arising on the penile shaft.

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