Striving to be the most comprehensive online resource for high-quality pathology images

 

Malignant Mesothelioma : Immuno-histochemistry

prev  
slide 33 of 48
next
No Image
Peritoneum_Mesothelioma_Immunos_Calretinin1.jpg

Close

Comments:
The immunohistochemical profile of malignant mesotheliomas is generally as follows: POSITIVE MARKERS: keratin 5/6, EMA, calretinin (shown here), mesothelin, WT1, thrombomodulin, HBME-1, podoplanin (D2-40), vimentin, NCAM, type IV collagen, and laminin. NEGATIVE MARKERS: CEA, B72.3, MOC-31, Ber-EP4, and Leu-M1. Podoplanin appears to be the most specific among positive markers. Some mesotheliomas express actin and desmin. In sarcomatoid mesotheliomas, the expression of some or all of the positive markers may be lost. Photograph copyright © 2011 Nephron. This image is used under the terms of GNU Free Documentation License Version 1.2

prev
slide 33 of 48
next