Striving to be the most comprehensive online resource for high-quality pathology images

 

Dysgerminoma : Genetics

prev  
slide 33 of 183
next
No Image
Ovary_GermCellTumors_Dysgerminoma10.jpg

Close

Comments:
Like seminomas, dysgerminomas show chromosome 12p abnormalities in the form of isochromosome 12p or 12p amplification in 80% of cases. About 25-50% of dysgerminomas have point mutations in c-kit which encodes for KIT - a tyrosine kinase receptor. The mutations are localized to exon 17, codon 816 and do not confer susceptibility to tyrosine kinase inhibitor imatinib. KIT mutations do not correlate with KIT protein expression. About one-third of cases show KIT amplification.

The image shows clusters of polygonal tumor cells with clear or lightly eosinophilic cytoplasm separated by delicate fibrous septa.

prev
slide 33 of 183
next