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Cirrhosis in Total Parenteral Nutrition

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Liver_Cirrhosis16_TPN.jpg

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In addition to steatosis and steatohepatitis, long-term total parenteral nutrition (TPN) may result in cholestasis, hepatocellular damage, ductular reaction, fibrosis, and cirrhosis. This case of TPN-induced cirrhosis shows damaged hepatocytes with steatosis and inspissated bile. The morphologic features may mimic those of bile duct obstruction.

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