Striving to be the most comprehensive online resource for high-quality pathology images

 

Pulmonary LCH : Morphology

prev  
slide 27 of 69
next
No Image
HemPath_LCH_Lung6D.jpg

Close

Comments:
Pulmonary Langerhans Cell Histiocytosis (LCH) - Morphology: The interstitial infiltrates are composed of clusters of Langerhans cells (LCs), variable number of eosinophils, pigment-laden macrophages, lymphocytes, plasma cells and neutrophils. Eosinophils may be entirely absent or so numerous as to produce eosinophilic microabscesses with central necrosis and Charcot-Leyden crystals.

Early lesions of LCH are cellular and show numerous LCs and eosinophils with minimal or no fibrosis. Later stages are dominated by fibrosis and foamy macrophages with decreased numbers of LC cells and eosinophils. LCs have moderate to abundant lightly eosinophilic cytoplasm and vesicular nuclei with grooves, folds and indentations.

prev
slide 27 of 69
next