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Diffuse Neurofibroma

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In contrast to conventional (localized) neurofibromas which show low cellularity and Schwann cells with wavy, pointed nuclei, diffuse neurofibromas are hypercellular and are composed of short fusiform or round Schwann cells which are present in a background of fine fibrillary collagen. They frequently show organoid structures resembling Meissner corpuscles (pseudo-Meissnerian structures), mature fat, or large ectatic blood vessels.

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