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Carcinoid of Thymus : Synaptophysin

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Mediastinum_Thymus_NE_Carcinoid18_Synaptophysin.jpg

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Immunohistochemistry: Thymic carcinoids are immunoreactive for keratins (AE1/AE3, CAM5.2; dot-like pattern) and neuroendocrine markers such as synaptophysin (shown here), chromogranin, and NCAM/CD56. They may also show focal positivity for hormones such as ACTH, hCG, somatostatin, and calcitonin. TTF-1 is not expressed.

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