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Spindle Cell Lipoma : Pseudoangiomatous Pattern

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An unusual pattern noted in some spindle cell/pleomorphic lipomas is the so-called pseudoangiomatous pattern. It consists of irregular branching spaces with villiform connective tissue projections lined by endothelial-like cells. Subsequent immunohistochemical studies have shown the cells to be positive for endothelial markers (hence true angiomatous pattern).

Image courtesy of: Dr. Ibrahim Zardawi; used with permission.

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