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Hepatosplenic T-cell Lymphoma

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Malignant T cells are small to intermediate in size with regular oval or folded nuclei; occasional cells may be larger with highly atypical nuclei. Two variants of hepatosplenic T cell lymphomas are known: Alpha-beta variant expresses T cell receptors alpha-beta and shows female preponderance (younger than 13 yrs. and older than 50 yrs). Gamma-delta variant expresses T cell receptor gamma-delta chains and is more common in young males. Both variants carry poor prognosis.

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