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Adenosis : HMWCK

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Immunohistochemical markers for basal cells are useful in confirming the diagnosis of adenosis in needle biopsies. As depicted in this image, some glands are completely negative; however, at least half of the glands show some immunoreactivity for basal cells with high molecular weight cytokeratin. Since the glands lacking basal cells are morphologically similar to those with patchy staining, the entire focus is considered benign.

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