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Alcoholic Steatohepatitis : Mallory-Denk Bodies

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The main pathologic features of alcoholic steatohepatitis include macrovesicular steatosis, hepatocellular damage, inflammation, and pericellular fibrosis. The hepatocellular damage manifests with hepatocyte ballooning, cytoplasmic clearing, and intracytoplasmic Mallory-Denk bodies (Mallory’s hyaline), as seen here, which consist of dense eosinophilic intracytoplasmic material and may be highlighted by p62, ubiquitin, or CK8/CK18 immunostains. Focal intracanalicular bile plugs (as seen here) and/or mild, non-zonal iron overload may also occur.

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