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Medulloblastoma with Extensive Nodularity

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The nodules are composed of a uniform population of tumor cells. The background is reticulin-free and is rich in neuropil-like tissue. Mitotic activity is not significantly increased. The cells often show streaming in parallel rows. Following chemotherapy and/or radiation therapy, this tumor may undergo further differentiation and become dominated by a population of ganglion cells. Like desmoplastic medulloblastoma, this variant also has favorable outcome as compared to the classic medulloblastoma.

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