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SLL in Lymph Node

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HemePath_CLL7_LNode_ProlifCenter.jpg

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Higher magnification of a proliferation center from a lymph node involved with CLL/SLL. It is composed of larger lymphoid cells (prolymphocytes or paraimmunoblasts) which have more abundant cytoplasm, more dispersed nuclear chromatin, and conspicuous nucleoli. The mitotic activity in such foci is increased resulting in a higher Ki-67 labeling index.

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