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Diffuse Large B-cell Lymphoma : Anaplastic variant

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This is a rare variant of diffuse large B-cell lymphoma characterized by the presence of highly anaplastic, bizarre cells that may be arranged in cohesive sheets simulating carcinoma. Some of the larger atypical cells may even resemble Reed-Sternberg cells. Besides irregular nuclei, the tumor cells show abundant cytoplasm, multiple nucleoli and frequent atypical mitoses.

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