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Common Wart (Verruca vulgaris)

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Common Warts (Verruca vulgaris): The upper layers of epidermis show large cells with vacuolated cytoplasm and pyknotic nuclei (koilocytosis). Koilocytes are more prominent in genital warts.

Koilocytosis is the result of a protein capable of disrupting cytokeratin network that is encoded by the early region E4 of HPV genome.

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