Dermal Analog Tumor
Dermal analogue tumor is a distinct variant of basal cell adenoma and is also referred to as membranous type of basal cell adenoma. They are frequently multicentric and unencapsulated with a strong male predilection (>90% of cases occur in men). Familial cases are associated with germline mutation of CYLD gene – a tumor suppressor gene on chromosome 16q12-q13. They may be associated with dermal cylindroma, trichoepithelioma, eccrine spiroadenoma and milia. The image shows a classic low power appearance of a dermal analogue tumor composed of a tumor cell islands separated by eosinophilic hyaline material mimicking dermal cylindroma. The tumor is well circumscribed and covered by a thin capsule. The upper part of the image shows the normal salivary gland.