Epidermodysplasia Verruciformis

Comments:
Epidermodysplasia verruciformis (EV) is a rare genodermatosis (genetic disorder with cutaneous expression) that results in abnormal susceptibility to cutaneous HPV infections (caused mostly by HPV5 and HPV8 of the beta genus) and a higher risk of non-melanoma skin cancers. It has also been referred to as Lewandowsky-Lutz syndrome. The transmission is autosomal recessive in most patients.

The clinical manifestations of EV become apparent during infancy or childhood and consist of hypo- or hyperpigmented, scaly, macular plane warts on trunk, face, neck, arms, dorsal hands and feet (sun-exposed areas).

The histologic features of EV consist of acanthosis, hyperkeratosis, and enlarged keratinocytes with bluish-gray cytoplasm in the upper layers of epidermis.

Additional images and discussion of epidermodysplasia verruciformis are here