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Helicobacter Pylori Gastritis & MALT Lymphoma

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Helicobacter pylori Gastritis & Gastric MALT Lymphoma: Normal stomach does not have mucosa-associated lymphoid tissue (MALT). Most cases of Gastric MALT lymphomas arise in acquired MALT associated with H. pylori infection. H pylori is detectable in gastric mucosa in the vast majority of gastric MALT lymphomas (85-90% of cases). Clonal B-cell populations have been demonstrated in biopsies with chronic gastritis preceding the development of lymphoma. Although the prevalence of H. pylori in general population is about 50%, only 1% will develop gastric adenocarcinoma or lymphoma. Antibiotic therapy for H. pylori is the first line of treatment and often induces remission in 80% of cases.

Additional Helicobacter species such as Helicobacter heilmannii have been implicated in the pathogenesis of gastritis, peptic ulcer disease, gastric carcinoma, and gastric MALT lymphomas.

The image shows chronic active gastritis with lymphoplasmacytic infiltrate and crypt abscesses. H. pylori were identified with Giemsa stain (next image). Image courtesy of: @PatholWalker.

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