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B-cell Prolymphocytic Leukemia : Microscopic

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Microscopic Features: By definition, prolymphocytes must make up > 55% of circulating lymphoid cells in B-cell prolymphocytic leukemia. Usually, this number exceeds 90%.

Prolymphocytes are twice the size of small lymphocyte and have a round or oval nucleus, slightly condensed chromatin, prominent central nucleolus, and scarce amount of faintly basophilic cytoplasm. The cells lack nuclear indentations, cytoplasmic hairy projections, or villi.

Image courtesy of: Kyle Bradley, MD; used with permission.

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