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Ependymoma

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Brain_Ependymoma_PseudoRosettes3.jpg

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Higher magnification of perivascular pseudorosettes. They consist of a collar of tumor cells arranged around blood vessels creating a nucleus-free zone immediately around the vascular lumen. True rosettes with a central lumen and canals lined by ependymal cells and resembling small ventricles are seen in about 10% of cases. Most typical ependymomas are considered WHO Grade II tumors (although the Myxopapillary variant is, by definition, WHO Grade I tumor). The anaplastic variant (discussed later) is WHO Grade III tumor.

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