Glioblastoma : Endothelial Proliferation

Comments:
Besides necrosis with nuclear pseudopalisading, the presence of endothelial proliferation is another histologic hallmark of glioblastomas. The image shows glomeruloid vessels (vessels with multiple lumina) and endothelial multilayering as a result of endothelial hyperplasia. These changes are driven by Vascular Endothelial Growth Factor (VEGF) secreted by the tumor in response to hypoxia.