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Glioblastoma : Endothelial Proliferation

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Brain_Astrocytoma_GBM5(1).jpg

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Besides necrosis with nuclear pseudopalisading, the presence of endothelial proliferation is another histologic hallmark of glioblastomas. The image shows glomeruloid vessels (vessels with multiple lumina) and endothelial multilayering as a result of endothelial hyperplasia. These changes are driven by Vascular Endothelial Growth Factor (VEGF) secreted by the tumor in response to hypoxia.

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