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Darier Disease

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Darier Disease: There is hyperkeratosis and dyskeratosis (manifested as corps ronds and grains). Corps ronds are large structures in the granular layer consisting of irregular, eccentric pyknotic nucleus with a clear halo and an eosinophilic or basophilic shell around it. Grains are flattened oval cells with elongated nuclei and numerous keratohyalin granules.

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