Darier Disease

Comments:
Darier Disease: There is hyperkeratosis and dyskeratosis (manifested as corps ronds and grains). Corps ronds are large structures in the granular layer consisting of irregular, eccentric pyknotic nucleus with a clear halo and an eosinophilic or basophilic shell around it. Grains are flattened oval cells with elongated nuclei and numerous keratohyalin granules.