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Darier Disease

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Darier Disease: There is hyperkeratosis and parakeratosis and acantholysis resulting in suprabasal cleft formation. Dyskeratosis is manifested as corps ronds and grains. Corps ronds are large structures in the granular layer consisting of irregular, eccentric pyknotic nucleus with a clear halo and an eosinophilic or basophilic shell around it. Grains are flattened oval cells with elongated nuclei and numerous keratohyalin granules. See higher magnification in the next image.

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