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Keratinizing Squamous Metaplasia

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This bladder biopsy is from a 78 y/o male with history of repeated urinary tract infections and urinary obstruction. Cystoscopy showed a whitish patch on the anterior bladder wall which was biopsied. Sections revealed keratinizing squamous metaplasia with hyperkeratosis and a granular cell layer. Keratinizing squamous metaplasia is a risk factor for development of squamous cell carcinoma and requires close follow-up.

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