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Urothelial Carcinoma-in-situ : Pagetoid spread

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UrinaryBladder_FlatLesions_CIS11.jpg

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Urothelial CIS may spread into the adjacent normal urothelium in a pagetoid fashion. Several individual tumor cells with features of CIS are present within the normal urothelium. The tumor cells have voluminous eosinophilic cytoplasm and enlarged hyperchromatic nuclei.

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