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Complex Endometrial Hyperplasia with Atypia

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The endometrial glands are highly irregular in size and shape and show frequent outpouchings. The atypia is characterized by enlarged round nuclei, irregular chromatin distribution, and prominent nucleoli. The morphologic features of complex hyperplasia with atypia overlap with those of well-differentiated adenocarcinoma and a distinction between the two may not always be possible on a biopsy.

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