Yolk Sac Tumor : Clinical Presentation

Comments:
Clinical Presentation: Pure yolk sac tumor (YST) occurs in children, adolescents and young adults (median age at presentation 19 years). About 25% of patients are prepubertal at diagnosis. It presents as a rapidly growing pelvic mass that can cause abdominal pain and distension. Hormonal manifestations (precocious puberty, hirsutism) and menstrual irregularities may occur but are far less common than with embryonal carcinoma. Serum AFP and CA125 levels are markedly elevated. Beta-hCG is normal. Imaging studies show a solid and cystic mass.

About this image: A large pelvic mass removed from a 14 y/o female. Serum AFP > 2000 ng/ml. Final diagnosis: Yolk Sac Tumor. Gross pathology is discussed in the next image. Image courtesy of: Dr. Gustavo Lastra, Merida, Yucatan, Mexico; used with permission.