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Clear Cell Carcinoma : Immunohistochemistry

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Clear cell carcinomas are diffusely positive for keratins, EMA, Leu-M1, and B72.3. Stains for CEA and CA-125 are positive in 40% to 50% of cases.

This image shows tumor cells arranged in sheets and papillary structures. They have hyperchromatic nuclei and prominent nucleoli.

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