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Clear Cell Carcinoma

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The most common cell types in clear cell carcinomas of the ovary are clear cells and hobnail cells. Clear cells line glandular structures or can be arranged in solid nests, clusters, and sheets (as seen here). They are polygonal in shape, have distinct cytoplasmic borders, and contain clear cytoplasm (due to glycogen; PAS-positive diastase sensitive). The nuclei are slightly enlarged. A few hyperchromatic atypical nuclei can be seen. Mitotic activity is not appreciably increased. The stroma contains abundant acute inflammatory cells.

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