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Giant Cell Arteritis : Clinical

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Cardiovascular_Arteritis_GiantCell3_ElasticVanGieosaStain.jpg

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Giant Cell Arteritis (GCA) - Clinical: GCA is a large vessel vasculitis, thought to be of autoimmune origin, usually seen in elderly patients. The most commonly affected are temporal, cerebral, and retinal arteries; however, it can also involve aorta and extracranial carotid artery branches.

The patients present with pain and tenderness in face and scalp, jaw claudication, and even blindness. About 50% of cases develop polymyalgia rheumatica consisting of pain and tenderness involving neck muscles, shoulder girdle, and pelvis.

This image shows partial disruption of internal elastic lamina with Verhoff van Gieson stain in a resected temporal artery from a case of giant cell arteritis.

Image courtesy of: @PatholWalker

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