Like spindle cell lipomas, the most common location for pleomorphic lipomas is subcutaneous tissues in shoulder, upper back, and posterior neck of adults with a predilection for men. They present as solitary, circumscribed, slow-growing, and painless lesions. Microscopically, the main finding is multinucleated giant cells with deeply eosinophilic cytoplasm and hyperchromatic nuclei in a wreath-like arrangement (floret giant cells). Other histologic features are similar to those seen in spindle cell lipomas, including collagen bundles, numerous mast cells, and myxoid stroma. Scattered lipoblasts may be seen and should not be used as a basis for the diagnosis of liposarcoma in the absence of other features.