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Spindle Cell Lipoma : Differential

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SoftTissue_Lipomatous_SpindleCellLipoma11.jpg

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Differentia Diagnosis of Spindle Cell Lipoma (continued from the previous image):

Schwannoma and neurofibroma (more prominent nuclear palisading than spindle cell lipomas; cells and their nuclei wavier or buckled; positivity for S-100 protein).

Myxoid liposarcomas (numerous lipoblasts; pleomorphic spindle cells; prominent plexiform vasculature; and absence of thick collagen bundles).

This image shows a sparsely cellular spindle cell lipoma consisting of scattered bland spindle cells and mature adipocytes in a myxoid stroma with ropey collagen bundles.

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