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Diffuse Large B-cell Lymphoma

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LymphNode_DiffuseLargeBCellLymphoma1.jpg

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The image shows sheets of centroblastic cells separated by areas of sclerosis. Diffuse large B-cell lymphomas (DLBCL) may exhibit significant sclerosis and hyalinization in some cases. The separation of DLBCL into centroblastic and immunoblastic variants is no longer pursued due to poor intra- and interobserver reproducibility.

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