Plasmablastic Lymphoma in a HIV+ male
The tumor cells were strongly positive for CD138. The median age at presentation is 39 years with a male:female ratio of 7:1. Plasmablastic lymphoma presents on average 6 years after the initial diagnosis of HIV and the CD4 counts are usually <200 cell/cu.mm. Commonly involved sites include oral cavity, GI tract and lymph nodes. Epstein Barr virus is detected in 75% of cases and human herpesvirus-8 in 16% of cases. Initial response to therapy may be good, but the long-term prognosis remains poor. Reference: J. Castillo, B. J. Dezube, L. Pantanowitz. J Clin Oncol 26: 2008 (May 20 suppl).