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Castleman's Disease : Plasma Cell Type

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LymphNode_CastlemansDz_PlasmaCellType4.jpg

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Multicentric or Systemic form of Castlemanís disease is usually of plasma cell type which shows diffuse plasma cell proliferation in the interfollicular region. The image shows a small follicle in the center with eosinophilic deposits of fibrin and immune complexes. Hyaline-vascular changes are absent. Plasma cell type of Castlemanís disease is often symptomatic and is accompanied by fever, anemia, elevated erythrocyte sedimentation rate, hypergammaglobulinemia, and hypoalbuminemia. In contrast, hyaline-vascular type is often asymptomatic.

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