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Chronic Myeloid Leukemia in Blast Transformation

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This 79 y/o female with chronic myeloid leukemia presented with rapidly enlarging spleen. The splenectomy specimen showed a dark red surface devoid of white pulp. Majority of the large tumor cells seen here were positive for CD34. This is a case of chronic myeloid leukemia in blast transformation (Richters Syndrome).

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