Striving to be the most comprehensive online resource for high-quality pathology images

 

Sclerosing Sertoli Cell Tumor

prev  
slide 57 of 104
next
No Image
Testis_SclerosingSertoliCellTumor4.jpg

Close

Comments:
Some cases of Sertoli cell tumor (SCT) have prominent hyaline fibrosis. The cellular component, which makes up less than 50% of the tumor, consists of compressed cords, trabeculae, small nests, and solid tubules in dense collagenous stroma.

This so-called "sclerosing Sertoli cell tumor" is now considered to be a morphologic variant of SCT rather than a separate entity. Like Sertoli cell tumor, NOS, the sclerotic variant also shows frequent mutations in CTNNB1 gene and nuclear positivity for beta-catenin. The clinical features are similar in both variants; however, the sclerotic variant appears to have a slightly better prognosis.

prev
slide 57 of 104
next