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Chordoma : Morphology

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Bone_Chordoma37.jpg

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Classic appearance of a conventional chordoma showing clusters of cells with abundant eosinophilic or vacuolated cytoplasm in a background of myxoid matrix. The vacuoles range from single small vacuoles creating a signet ring cell appearance to multiple vacuoles imparting a soap bubble appearance (physaliphorous cells).

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