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Seminoma : OCT3/4 Immunostain

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Testes_Seminoma60_OCT34.jpg

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OCT3/4 is a transcriptional regulator that is expressed in embryonic stem cells and germ cells. It is a quite sensitive and a specific marker of both seminoma and embryonal carcinoma (positive in >98% of cases). The staining pattern is nuclear as seen in this image. OCT3/4 expression is also seen in intratubular germ cell neoplasia, unclassified.

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