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Pancreatoblastoma : Treatment

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Pancreas_Pancreatoblastoma19.jpg

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Treatment: Pancreatoblastomas are indolent tumors but they can be locally invasive and metastasize. Involvement of adjacent structures such as spleen, duodenum, colon, portal vein, and common bile duct is sometimes seen. About 35% of patients have metastases at presentation. The usual sites are liver, regional lymph nodes, and lung.

The treatment consists of complete surgical resection which may be followed by chemotherapy and radiation therapy. Autologous hematopoietic stem cell transplantation has been successfully done following resection in a small number of patients. Patients with recurrent, residual, unresectable, or metastatic tumors are treated with doxorubicin and cisplatinum-based chemotherapy.

The image shows three large squamoid nests in a pancreatoblastoma.

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