Striving to be the most comprehensive online resource for high-quality pathology images

 

Acinar Cell CA : Microscopic

prev  
slide 3 of 26
next
No Image
Pancreas_AcinarCellCA_4B.jpg

Close

Comments:
Architecture: Acinar cell carcinomas (ACC) are quite cellular and show lobular growth with scant stroma. Necrosis is common.

Within the lobules, the cells are arranged in a variety of architectural patterns which are shown in this and the next 3 images. The most common patterns are acinar and solid patterns. Multiple patterns usually coexist within a given tumor. Acinar pattern (shown here) consists of tightly packed structures resembling rosettes or normal pancreatic acini. They are composed of a single layer of cells with basal nuclei, radially arranged around a small lumen.

In glandular pattern, there are larger acinar structures with dilated lumina and pseudostratified nuclei. In trabecular pattern, the cells are arranged in anastomosing ribbons with strong resemblance to pancreatic neuroendocrine tumors. The solid areas consist of sheets of tumor cells without any discernible lumina.

Uncommon histologic/cellular patterns include oncocytic, spindle cell, clear cell, and pleomorphic types. Some cases show intraductal or papillary growth. There are no squamoid nests - a useful differentiating feature from pancreatoblastoma.

prev
slide 3 of 26
next