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Fatty Liver of Pregnancy

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Acute fatty liver of pregnancy is more frequently associated with first pregnancies, twin gestations, and male fetuses. It generally occurs late in the third trimester or in the immediate post-partum period. Histologic features include microvesicular steatosis and ballooning hepatocyte degeneration. Note the involvement pericentral hepatocytes (left half) with relative sparing of the periportal hepatocytes (right half).

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