Hodgkin Lymphoma : Spleen

Comments:
Splenic Involvement in Hodgkin Lymphoma: Spleen involvement is suggested by palpable splenomegaly and can be confirmed by imaging studies such as fludeoxyglucose - positron emission tomography (FDG-PET) or CT. Findings on FDG-PET include diffuse uptake, solitary mass, multiple large nodules, or miliary lesions.

Spleens involved by Hodgkin lymphoma usually weigh > 400 grams. The disease may be focal and some cases have small inconspicuous nodules that requres meticulous sectioning.

Grossly, there may be a single or a few large nodules (shown here) or multiple smaller nodules with a miliary distribution (next image). The number of tumor nodules has prognostic implications and should be noted (more specifically, it should be mentioned whether there are five or more nodules).

The image shows classic Hodgkin lymphoma, nodular sclerosis, involving spleen.