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NLPHL : PD1

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HemePath_NLPHL69_PD1(1).jpg

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Nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL): Most lymphocyte-predominant (LP) cells are surrounded by T cells expressing CD3, CD4, CD57, and PD1 forming rosettes or collarettes. This image shows PD1 positive T-cells forming rosettes around LP cells.

The presence of T-cell rosettes around CD20+, BCL6+ LP cells is a useful diagnostic feature of NLPHL and helps distinguish it from progressively transformed germinal centers, mixed cellularity Hodgkin lymphoma, and T cell/histiocyte-rich B cell lymphoma.

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