Diffuse large B-cell lymphoma (DLBCL) of the spleen in a 65 y/o female who presented with splenomegaly. Splenectomy specimen measured 19.5 cm in greatest dimension. The cut surface shows near-total replacement of splenic parenchyma by a fleshy, pink-tan tumor. The diagnosis of DLBCL was confirmed with immunostains. Courtesy of: Dr. Sanjay D. Deshmukh & Dr. Shridhar V. Babanagare, Dept. of Pathology, Smt. Kashibai Navale Medical College, Pune, India.