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Fibrolamellar Carcinoma of Liver

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FLC may contain foci of trabecular and/or acinar (pseudoglandular) architecture with little intervening stroma, as seen here. The tumor cells still bear a striking resemblance to native hepatocytes, with abundant cytoplasm and distinct cell borders. The large nuclei, prominent nucleoli, and cellular atypia are characteristic of hepatocellular malignancies.

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