Neuroblastoma Maturation : Post-Chemotherapy
The histologic changes in neuroblastomas induced by chemotherapy/radiation therapy include extensive necrosis, hemorrhage, hemosiderin deposition (shown here), fibrosis, and calcification along with varying degrees of tumor maturation. This image shows maturation to ganglioneuroblastoma following chemotherapy. The differentiating neuroblasts have moderate to abundant acidophilic or amphophilic cytoplasm and an enlarged eccentric vesicular nucleus with a single prominent nucleolus. There is abundant neuropil in the background.