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Giant Cell Tumor of Bone

slide 6 of 17

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There is female predominance, especially in the first two decades of life. Peak incidence is in the third decade. Pain and swelling are common presenting symptoms. The image shows a typical case with numerous multinucleated giant cells scattered in a background of uniform mononuclear cells. The giant cells are believed to arise from the fusion of these mononuclear cells.

slide 6 of 17